When is a predose a dose too much?

When there is too much light.

A great deal of importance has happened in research investigating photosynthetic response to environmental stress in the 25 years since the last anniversary issue of Plant Physiology. However, from my perspective, the importance of one set of discoveries stands out from the others for its far reaching influence on how we think about the photosynthetic response to a wide range on environmentally...

Kernel Plugins: When a VM Is Too Much

This paper presents kernel plugins, a framework for dynamic kernel specialization inspired by ideas borrowed from virtualization research. Plugins can be created and updated inexpensively on-the-fly and they can execute arbitrary user-supplied functions such that neither safety nor performance are compromised. Three key techniques are used to implement kernel plugins: (1) hardware fault isolati...

How much vitamin A is too much?

Optimal Aminoglycoside Therapy Following the Sepsis: How Much Is Too Much?

Severe sepsis and septic shock are major problems as the result of high rates morbidity andmortality in intensive care units (ICUs). In the presence of septic shock, each hour of delay inthe administration of effective antibiotics is associated with a measurable increase in mortality.Aminoglycosides are effective broad-spectrum antibiotics that are commonly used in ICUs forthe treatment of life...

Optimal Aminoglycoside Therapy Following the Sepsis: How Much Is Too Much?

Severe sepsis and septic shock are major problems as the result of high rates morbidity andmortality in intensive care units (ICUs). In the presence of septic shock, each hour of delay inthe administration of effective antibiotics is associated with a measurable increase in mortality.Aminoglycosides are effective broad-spectrum antibiotics that are commonly used in ICUs forthe treatment of life...